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Mls 2206: General And Systemic Pathology Question Paper

Mls 2206: General And Systemic Pathology

Course:Bachelor Of Science In Medical Laboratory Science

Institution: Jomo Kenyatta University Of Agriculture And Technology question papers

Exam Year:2012

JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
UNIVERSITY EXAMINATIONS 2012/2013
EXAMINATION FOR THE DEGREE OF BACHELOR OF SCIENCE IN MEDICAL LABORATORY SCIENCE
MLS 2206: GENERAL AND SYSTEMIC PATHOLOGY
DATE: AUGUST 2012 TIME: 2 HOURS

1. With congo red stain, amyloid stains
a) Red
b) Salmon pink
c) Bluish
d) Purple

2. Endocrine amyloidis is associated with the following conditions EXCEPT
a) Type II diabetes
b) Type I diabetes
c) Pheochromocytoma
d) Thyroid catcinoma

3. Hydropic degeneration is also known as
a) Cell swelling
b) Cell drinking
c) Cell eating
d) Cell movement

4. Gaucher’s disease is due to deficiency of the enzyme
a) Insulin
b) Glucocerebroisase
c) Amylase
d) Peptidase

5. Programmed or planned cell death is also known as
a) Necrosis
b) Autolysis
c) Apoptosis
d) Lipolysis

6. Skeletal muscle injury is accompanied by release of the following intracellular enzyme
a) Creatine kinase (MB isoform)
b) Aspartate transaminase
c) Lactate dehydrogenase
d) Creatine kinanse (MM isoform)

7. Which of the following is one of the leading cancers in Kenya women
a) Lung cancer
b) Bone cancer
c) Cervical cancer
d) Prostate cancer

8. An ulcer with a punched – out edges most likely signifies
a) Syphilis
b) Squamous cell carcinoma
c) Tuberculosis
d) Granulation tissue formation

9. Histamine is mainly stored in the following except
a) Connective tissue nast cells
b) Blood basophils
c) Platelet granules
d) Neutrophils

10. Fluid exudates from the mucous membranes is referred to as
a) Catarrhal
b) Prulent
c) Fibrinous
d) Serous

11. Bad generalised oedema is called
a) Ascites
b) Anasacra
c) Hydrothorax
d) Hydrocephalus

12. A malignant cancer of bone is called
a) Rhabdomyosarcoma
b) Chondrosarsma
c) Haemangiosarcoma
d) Osteosarcoma

13. Decreased blood flow from an organ is referred to as
a) Hyperemia
b) Hematoma
c) Congestion
d) Ecchymoses

14. Which of the following is correct regarding classification and nomendature of neoplasms
a) The histogenesisi of a tumor refers to its behavior
b) An ancathoma is a benign tumor of glandular epithelium
c) A carcinoma is an epithelical malignancy
d) Leiyomyosarcoma is a malignant tumor of skeletal muscle

15. Which of the following inflammatory cells are associated with allergy and reactions to parasitic infection
a) Eosinophilis
b) Ventrophilis
c) Macrophoyes
d) Fibroblasts

16. A 50 years old male present with epigastric pain that improves on taking meals. Endoscopy demonstrates a 2 cm ulcerated area located 3-cm distal to the pyloric junction Basal arid output is within normal limits. Which of the following is most likely to have made the strongest contribution to the development of this disease
a) Aspirin use
b) Drinking alcohol
c) Chronic antacid use
d) Helicobacter pylori infection
17. Karyorrhexis refers to

a) Chromatin condensing around the periphery of the nucleus
b) Small dense nuclei
c) Complete lysis of the nuclei
d) Fragmented nucleus generally seen in apoptosis

18. A pap smear ofa 27 – years old woman demonstrates squamous cells with enlarged, hyperchromatic nuclei and a prominent pronuclear halo. The Pap smear is graded as cervical intraepithelial neoplasia grade II. Which of the following viruses is most likely to be etiologically related to this neoplastic growth
a) Human herpes 8 virus
b) Human papilloma virus
c) Hepatitis B virus
d) Epstein – Barr virus

19. Necrosis
a) May be a physiological process
b) Is a well controlled form of cell death
c) Of the coagnative type is the commonest form
d) Of the caseous type typically follows infarction

20. Repair is the regeneration of vascular, fibrons connective tissue and it is characterised by the proliferation and maturation of the tissue in order to
a) Replace the loss of more specialised tissue
b) Replace inflammatory exudates and haemorrhage
c) Replace mitochondria and Rough endoplasmic recticulum
d) Replace thrombus within blood vessels

SECTION B (30 marks) – ANSWER ALL QUESTIONS
21. Define necrosis and outline the various types of necrosis (6 marks)
22. Outline the injury that may occur to the nucleus (6 marks)

23. Define the following terms
a) Ascites [1 mark]
b) Hydropericadium [1 mark]
c) Hydrocephalus [1 mark]
d) Blister [1 mark]
e) Haemothorax [1 mark]
f) Haematochezia
[1 mark]
24. Briefly outline the following
a) Oedema (3 marks)
b) Haemorrhage (3 marks)

25. Explain the following terms
a) Aneurysm (3 marks)
b) Cellulitis (3 marks)
c) Granulomation (3 marks)

SECTION C (20 marks) Answer one question
26. a) outline the pathogenesis of primary tuberculosis (10 marks)
b) Outline the pathophysiology of coagulation neurosis (10 marks)
27. Discuss healing by regeneration and repair (20 marks)
28. Outline the grading and staging of tumors and list the four most common cancers in Kenya (20 marks)

Mls 2206: General And Systemic Pathology Question Paper

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