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Mls 2207: Clinical Haematology 1 Question Paper

Mls 2207: Clinical Haematology 1

Course:Bachelor Of Science In Medical Laboratory Science

Institution: Jomo Kenyatta University Of Agriculture And Technology question papers

Exam Year:2012

JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
UNIVERSITY EXAMINATIONS 2012/2013
EXAMINATION FOR THE DEGREE OF BACHELOR OF SCIENCE IN MEDICAL LABORATORY SCIENCE
MLS 2207: CLINICAL HAEMATOLOGY 1
DATE: AUGUST 2012 TIME: 2 HOURS

SECTION A
1. Nuclear and cytoplasmic maturation in iron deficiency anaemia is
a) Synchronous
b) Over developed
c) Incomplete
d) Asynchronous

2. Neutrophilia is caused by:-
a) Viral infections
b) Bacterial infections
c) Agranulocytosis
d) Low platelet count.

3. Haemoglobin A1 is consist of
a) 2 delta and 2 Beta polypeptide chains
b) 2 alpha and 2 Beta polypeptide chains
c) 2 Zeta and 2 alpha polypeptide chains
d) 2 gamma and 2 alpha polypeptide chains

4. Red blood cell generate energy;
a) As ATP by the embden meyerhoff pathway
b) By help of its nucleus
c) To synthesize haemoglobin
d) To help WBC survival in the circulation

5. The following are characteristics of stem cell;
a) Stem cells when committed are found in circulation.
b) Stem cells must be capable of developing along various cell lines
c) They are not capable of replication
d) Stem cells are identified under the microscope morphological.
6. The following are unstable haemoglobins:-
a) Hb A2
b) Hb Kohn
c) Hb F
d) Hb S

7. The normal values for ESR in mm/hr are
a) 0 – 10
b) 0 – 20
c) 20 – 30
d) 0 – 2

8. The following are normal forms of Haemoglobin:-
a) Carboxyhaemoglobin
b) Methaemoglobin
c) Cyanmethaemoglobin
d) Deoxyhaemoglobin

9. A revesion to fetal sites (liver and spleen) of hematopoiesis in adults is:-
a) Physiological response to blood cells demand.
b) Evidence that hematopoietic stem cells may be foun in peripheral blood.
c) A response to decreased requirement for cell production
d) Is an indicator of bone marrow hypoactivity

10. Unconjugated bilirubin:-
a) Uptake takes place in the bone marrows.
b) Leave plasma albumin and is taken by the hepatocytes
c) Is oxidized in colon to a brown pigment
d) May cause kernicterus in newborns

11. Hemoglobin affinity for O2 is regulated by:-
a) Globulins
b) Heme
c) Iron
d) 2, 3 DPG

12. The rate of erythropoiesis is governed by:-
a) The rate of oxygen delivery to the tissues
b) A hormone produced by the liver
c) The amount of thrombopoietin released
d) The organs of extramedullary haematopoisis

13. The following RBC abnormalities belong to etiologic classification of anemia:-
a) Normocytic normochromic anaemia
b) Macrocytic anaemia
c) Excessive RBC destruction
d) Microcytic anaemia

14. An increased MCV is associatedwith:-
a) Macrocytic anemia
b) Microcytic anemia
c) Thalassaemia
d) Deficiency of RBC production essential element.
15. Relative erythrocytosis is caused by a (n):-
a) Decreased plasma volume
b) Decreased RBC mass
c) Increase in both red blood celland plasma volume
d) Increase in red bloob cell mass
16. The major site(s) of hematopoiesis in a embryo is:-
a) Liver
b) Spleen
c) Yolk sac
d) Lymph nodes
17. When a Hemoglobin molecule is in ‘R’ state:-
a) A low oxygen affinity is conferred
b) The dimers are wide apart
c) It has a high oxygen affinity
d) It binds 2 – 3 DPG between the climers.
18. The genetic defect that characterizes most thalassemias is:-
a) Abnormal incorporation of iron into heme
b) Decrease production of normal globin chains
c) Excessive production of porphyrins
d) Increased production of abnormal globin chains.
19. The most common cause of heamoglobinopathies is an abnormality in the globin chain.
a) Alpha
b) Beta
c) Gamma
d) Delta
20. Abnormal Hb are more often caused by:
a) Amino acid substitutions
b) Amino acid deletions
c) Globin chains elongations
d) Globin chains fusions.
SECTION B
21. Describe six normal types of Haemoglobin molecules. (6 Marks)
22. Write or extremedullary Haematopoiesis. (6 Marks)
23. Outline characteristics of a stem cell. (6 Marks)
24. Classify qualitative Hemoglobinopathies. (6 Marks)
25. Outline characteristics of anticoagulants. Give two examples of anticoagulants used in Haematological investigations.
SECTION C
26. In detail discuss sickle cell disease crisis.
27. Classify different types of anaemia.
28. Discuss red blood destruction and Haem degradation.

Mls 2207: Clinical Haematology 1 Question Paper

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