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Mls 2301: Clinical Chemistry Ii Question Paper
Mls 2301: Clinical Chemistry Ii
Course:Bachelor Of Science In Medical Laboratory Science
Institution: Jomo Kenyatta University Of Agriculture And Technology question papers
Exam Year:2012
JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
UNIVERSITY EXAMINATIONS 2012/2012
EXAMINATION FOR THE DEGREE OF BACHELOR OF SCIENCE IN MEDICAL LABORATORY SCIENCE
MLS 2301: CLINICAL CHEMISTRY II
DATE: AUGUST 2012 TIME: 2 HOURS
SECTION A Answer all
Each question has 4 items (a,b,d,d) and only one is correct.
Do not guess, half a mark will be deducted for every wrong response.
No mark for blank response
1. In regard to nephelometry
a) The intensity of scattered light is measured
b) The intensity of the light through the medium, unscattered light is measured
c) Radiant energy when an electron returns to a lower energy level is measured
d) Widely used for measurements of Aluminium
2. In electrophoresis, the movement of molecules in an electric field depend on all the following except
a) Strength of all electric field
b) The charge on the molecules
c) Shape and size of the molecules
d) Atomization of the molecules
3. Immunofixation
a) Is done when there is an M spike in the gamma region
b) Plays a role in diagnosis of hypoalbuminaemia
c) Done if there is an M spike in the Alpha region
d) Uses chemiluminiscene technique
4. In chromatography
a) Liquid chromatography is a form of planar chromatography
b) Thin layer chromatography is a form of planar chromatography
c) Gas chromatography is a form of planar chromatography
d) Paper chromatography include all expect
5. Applications of chromatography include all except
a) Analysis of metabolites and drugs
b) Analysis of vitamins
c) Analysis of nucleic acid
d) Analysis of electrolytes
6. The following are true of radioimmunoassay except
a) Measures small amounts of hormones or drugs
b) Hazards labeling using radiolabels
c) Lack of disposal mechanisms
d) Chemiluminiscene is used as labels
7. Radionuclides used in immunoassays include all except
a) Carbon 14
b) Iodine 125
c) Iodine 131
d) Potassium 121
8. The following are laboratory requirements for therapentic drug monitoring expect
a) Accurate
b) Sensitive
c) Quality assurance is not necessary since there is little variation in the analysis
d) Reproducible
9. In regard to tumour markers
a) CEA is elevated in colon cancer
b) PSA is not elevated in benign prostatic hyperplasia
c) Alpha HCG is more specific that Beta HCG
d) Alpha feto protein is elevated in fibroids
10. True of PSA
a) Is cancer specific
b) Is increased in prostatitis
c) Age adjusted reference values have no role in increasing sensitivity
d) PSA has no role in monitoring therapy
11. The labels used in immunoassays includes all except
a) Enzymes
b) Radio-isotopes
c) Magnetic labels
d) Electrophorescent
12. In regard to immunoassays
a) Heterogenous immunoassays require separation of the bound Ab-Ag complex
b) Non competitive assays are not used for cardiac markers
c) Noncompetitive assays are not used for hepatitis markers
d) The hook effect occurs at low analyte concentrations
13. Enzyme labels commonly used in enzyme immunoassay
a) Alkaline phosphatase from calf intestine
b) Catalase from horseradish
c) Gatalase from staphylococcus aureus
d) Urease fromcalf liver
14. The following are concepts used in fluorescence polarization immunoassay except
a) Fluorescence
b) Chemiluminescent labels
c) Rotation of molecules in solution
d) Polarized light
15. The following are common applications of point of care testing except
a) Glucose testing
b) Haematocrit
c) Drugs of abuse
d) Blood gases
16. Internal quality control includes all except
a) Pre-analytical analysis
b) Analytical
c) Post-analytical
d) Inter-laboratory analysis
17. The following are involved in analytical control except
a) Instrument calibration
b) Control charts
c) Use of reference standards
d) Mixing of blood sample with adequate anticoagulant
18. The following are true of pipettes in analytical laboratory except
a) Manual transfer
b) Micropipettes for measuring
c) Electric and mechanical pipettes devices
d) Part of centrifugation
19. The following are important charts in quality control except
a) Levey Jenny’s charts
b) Westgard multiple rules
c) Delta checks
d) Input output charts
20. Important samples in porphyria analysis include
a) Hair
b) Urine
c) Nails
d) Bone
SECTION B Answer all (6 marks)
21. List the applications of immunoassays
22. Outline the indications of therapentic drug monitoring
23. Enumerate the uses of tumour markers
24. Briefly describe separation techniques in chromatography
25. Outline the importance of automation.
SECTION C Answer only one question (20 marks)
26. Briefly describe 4 analytical techniques and their clinical applications
27. Discuss quality assurance
28. Discuss immunoassays
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