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Mls 2309: Clinical Mycology Question Paper

Mls 2309: Clinical Mycology

Course:Bachelor Of Science In Medical Laboratory Science

Institution: Jomo Kenyatta University Of Agriculture And Technology question papers

Exam Year:2012

JOMO KENYATTA UNIVERSITY
OF AGRICULTURE AND TECHNOLOGY

University Examinations 2012/2013

EXAMINATION FOR THE DEGREE OF BACHELOR OF SCIENCE IN MEDICAL LABORATORY SCIENCE

MLS 2309: CLINICAL MYCOLOGY

DATE: AUGUST 2012 TIME: 2 HOURS

INSTRUCTIONS:

• ANSWER ALL QUESTIONS IN SECTION A AND B AND ONLY ONE QUESTION IN SECTION C.
• A WRONG ANSWER OR GUESS WORK WILL RESULT IN A PENALTY OF 0.5 MARKS

SECTION A - ANSWER ALL QUESTIONS

1. 10 – 20% KOH in wet preparation is used for:

a) To stain skin specimen

b) To digest keratin

c) To soften hyphae

d) Show septa clearly

2. Nigrosin or Indian ink preparation demonstrates

a) Septa of hyphae

b) Inclusion bodies in yeasts

c) Capsule of some yeasts

d) Cell-wall of hyphae

3. Zygomycete fungi

a) Produce sporangium

b) Has septate hyphae

c) Show dimorphism

d) Produce arthrspores

4. Trichophyton mentegrphytes has

a) Reflexive hyphae

b) Anther hyphae

c) Spiral hyphae

d) Racket hyphae

5. Flask shaped conidia is associated with

a) Cladosporium carrions

b) Phialophora pendrosoi

c) Fonselea compactum

d) Allescheric bodydii

6. One of the following is not dimorphic fungi

a) Sporothric schenckii

b) Histoplasma capsulatum

c) Coccidioides immitis

d) Aspergillus fumugatus

7. Germ tube test demonstrates

a) Blastophores of candida

b) Pseudohyphae of candida

c) Ascus of candida

d) Buds of candida

8. Blastomyces, dermatitidis show one of the following:

a) Single budding yeast

b) Bipolar budding yeast

c) Multipolar budding yeast

d) Non-budding yeast

9. One of the following antifungal agent in injectable:

a) Ketoconazole

b) Fluconozole

c) Griseolfulvin

d) Itraconazole

10. Both Cryptococcus neoformans and Candida albicans are yeast. They are distinguished by:

a) Number of buds

b) One is capsulated

c) One is urease positive

d) Both ferment glucose

11. Norcardia asteroides show one of the following properties:

a) Gram positive yeast

b) Have club shaped swellings

c) Produce chlamydospores

d) Acid fast bacilliform

12. Chromoblasmycosis is characterized by the following features except:

a) Cauliflower papilloma

b) Sattelite modular crops

c) Raised warty lesions

d) Abscesses with pus

13. Disease of one of the following fungi mimic tuberculosis:

a) Aspergillus flavus

b) Histoplasma capsulatum

c) Penicillium marneffei

d) Cryptococcus neoformans

14. The main antigens of candida albicans detected in serum is:

a) Galactomannan

b) Mannan

c) Lipopolysoccharide

d) Lipoproteins

15. Chlamydospores have the following characteristics except:

a) Arise from hyphae

b) Have thick wall

c) Resist high temperature

d) Exhibit high basal metabolism

16. Fungi showing tuberculate macrocomidia with prosections on their surface is:

a) Histoplasma capsulatum

b) Geotrichum candidum

c) Aspergillus fumigatus

d) Penicillium rugulosa

17. Prerequisite for proper fungal diagnosis include the following except:

a) History of disease

b) History of treatment

c) History of travel

d) History of family

18. Most antifungal agents target

a) Chitin synthesis

b) Ergosterol biosynthesis

c) DNA synthetase

d) Ribosomal activity

19. Ideal empterature to store CSF before isolation of fungal agents is:

a) 0ºC

b) 25ºC

c) 37ºC

d) 40ºC

20. The effects of citrinin mycotoxin is:

a) Enlarged uterus

b) Enlarged kidney

c) Enlarged liver

d) Enlarged nipples

SECTION B – ANSWER ALL QUESTIONS (6 MARKS EACH)

21. Draw labeled diagrams of the following fungal structures:

a) Ascospores (2 marks)

b) Chlamydospores (2 marks)

c) Basidiospores (2 marks)

22. Compare fungi and bacteria. (6 marks)

23. a) Discuss the clinical condition of Tinea of dermatophytes. (2 marks)

b) Name four types of tinea conditions. (2 marks)

c) Name four species of Trichophytous. (2 marks)

24. Describe the clinical condition of mycotic mycetoma. (6 marks)

25. Explain the general rules for good fungal specimen. (6 marks)

SECTION C – ANSWER ONLY ONE QUESTION

26. Discuss candida infections. (20 marks)

27. Discuss Aflotoxins and Aflatoxicosis. (20 marks)

28. Discuss Histoplasmosis. (20 marks)

Mls 2309: Clinical Mycology Question Paper

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