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Mls 2506: Medical Immunology Question Paper

Mls 2506: Medical Immunology

Course:Post Graduate Diploma In Medical Laboratory Sciences

Institution: Jomo Kenyatta University Of Agriculture And Technology question papers

Exam Year:2012

JOMO KENYATTA UNIVERSITY
OF
AGRICULTURE AND TECHNOLOGY

University Examinations 2012/2013
EXAMINATION FOR THE POSTGRADUATE DIPLOMA IN MEDICAL LABORATORY SCIENCES

MLS 2506: MEDICAL IMMUNOLOGY

DATE: AUGUST, 2012 TIME: 3 HOURS

INSTRUCTIONS: Answer ALL Questions in Section A and B and ONLY ONE in Section C.

SECTION A

1. Which of the following is not an activation protein of complement:

a) Properdin
b) Factor B
c) Factor D
d) C3

2. The variable region of the immunoglobulin is located at:

a) VLCH domain
b) CHCL domain
c) VLVH domain
d) VLVL domain

3. Which of the following provides an interface between specific and non-specific immunity?

a) Neutriphils
b) Immunoglobulin A
c) Macrophages
d) Eosinophils
4. The majority of cells of the cortex of the lymph node are:

a) B-cells
b) T-cells
c) Dendritic cells
d) Macrophages

5. Which of the following is not a secondary lymphoid organ?

a) Peyers palahes
b) Tonsils
c) Spleen
d) Thymus

6. Antigen presenting cells present antigens to:

a) T-helper cells
b) T-cytotoxic cells
c) B-cells
d) Naïve T-cells

7. Which of the following immunoglobulins is present in serum in the lowest concentration?

a) IgG
b) IgA
c) IgM
d) igD

8. The following are involved in Anaphylactic hypersensitivity except:

a) IgG
b) IgE
c) Mast cells
d) Histamine

9. All the following are true with respect to IgM antibodies except:

a) They fix complement
b) They occur on the surface of lymphocytes
c) They are glycoproteins
d) They are antibodies of the primary immune response

10. The order of activation of the proteins of complement:

a) C C C C C
1 4 2 3 5
b) C C C C C
1 2 3 4 5

c) C C C C C
2 1 4 5 3

d) C5 C4 C3 C2 C1

11. Which of the following is typical of Type III hypersensitivity?

a) Atopy
b) Rheumatoid arthritis
c) Tuberculosis
d) Pernicious anaemia

12. CD8 cells recognize antigens in association with:

a) MHC class I
b) MHC class II
c) HLA
d) MHC

13. The paracortical area of a lymph node comprises mainly of:

a) Follicular dendritic cells
b) Plasma cells
c) Macrophages
d) B-cells
14. Which of the following antigens is not based on source:

a) Tolerogen
b) Autoantigen
c) Xenoantigen
d) Isoantigen

15. The immunogenicity of an antigen can be enhanced with:

a) Hapten
b) Carrier
c) Antibody
d) Adjuvant

16. Regulation of the alternative pathway is by:

a) C1 Inhibition
b) Factor B
c) Factor D
d) CRI

17. Graft rejection is mediated by:

a) T-lymphocytes
b) B-lymphocytes
c) Complement
d) All the above

18. The major cytokine involved in maturation of eosinophils is:

a) IL - 5
b) IL - 1
c) IL - 6
d) IL - 11

19. Which of the following bacteria evade host immunity by antigenic variation?

a) Neisseria gonorrheae
b) Mycobacterium tuberculosis
c) Mycobacterium leprae
d) Listeria monocytogenes

20. Which of the following viruses causes functional impairment of immune cells?

a) Herpes simplex
b) Epstein Barr Virus
c) Hepatitis B
d) Cytomegalo virus

SECTION B – ANSWER ALL QUESTIONS (6 MARKS EACH)

21. Describe the characteristics of MHC and distinguish MHC class I and II.

22. Describe the Killing mechanisms during phagocytosis.

23. Discuss the consequencies of complement deficiency.

24. Distinguish Type III and IV hypersensitivity reactions. Give examples of each.

25. Describe briefly immune responses to viruses.

SECTION C – ANSWER ANY ONE QUESTION (20 MARKS)

26. Write an essay on immunity to bacteria.
27. Discuss immunotherapy to tumours.

28. Describe the autogeny and phylogeny of the immune system.

Mls 2506: Medical Immunology Question Paper

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