Dbio 031: Immunology Question Paper
Dbio 031: Immunology
Course:Medical Laboratory Sciences
Institution: Kenya Methodist University question papers
Exam Year:2012
KENYA METHODIST UNIVERSITY
END OF 2''ND ''TRIMESTER 2012 (DAY) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : MEDICAL LABORATORY SCIENCES
UNIT CODE : DBIO 031
UNIT TITLE : IMMUNOLOGY
TIME : 3HOURS
INSTRUCTIONS: Answer ALL Questions in Section A and B and ONE Question in Section C
SECTION A (20MARKS)
QUESTION ONE
Which of the following is not part of the innate immune system
A. Mast cells
B. Complement
C. Phogocytes
D. T cells
QUESTION TWO
Which antibody is best at agglutination and complement fixation?
A. Ig A
B. Ig G
C. Ig D
D. Ig M
QUESTION THREE
All of the following are true of IgE except that it
A. Fails to fix complement
B. Is heat iabile
C. Attaches to tissues mast cells
D. Is found in the serum of allergic persons
QUESTION FOUR
Which of the following peripheral blood cells plays a key role in killing parasites?
A. Neurotrophils
B. Monocytes
C. Lymphocytes
D. Eosinophils
QUESTION FIVE
The classical complement pathway is activated by
A. Most viruses
B. Antigen-antibody complexes
C. Fungal cell walls
D. All of the above
QUESTION SIX
Which of the following white blood cells is capable of further differentiation in the tissues?
A. Neutrophil
B. Eosinophil
C. Monocytes
D. Basophil
QUESTION SEVEN
The structure formed by the fusion of engulfed material and enzymatic granules within the phagocytic cell is called
A. Phagosome
B. Lysosome
C. Vacuole
D. Phagolysosome
QUESTION EIGHT
All of the following are features of malignancy except
A. Excess apoptosis
B. Rapid proliferation
C. Clonal proliferation
D. Chromosomal mutations
QUESTION NINE
All of the following are ways that bacteria can evade host defenses except
A. Presence of capsule
B. Stimulation of chemotaxis
C. Production of toxins
D. Lack of adhesion to phagocytic cells
QUESTION TEN
How many antigen binding sites does a typical IgM molecule have?
A. 5
B. 2
C. 10
D. 1
QUESTION ELEVEN
The class of immunoglobulin is determined by
A. The light chain
B. The variable region
C. The J-chain
D. The heavy chain
QUESTION TWELVE
Undifferentiated lymphocytes are made in the
A. Bone marrow
B. Thymus
C. Spleen
D. Lymph nodes
QUESTION THIRTEEN
Which of the following are found on mature B cell?
A. IgG and IgD
B. IgM and IgD
C. Alpha and beta chains
D. CD3
QUESTION FOURTEEN
Which of the following is true of MHC class II antigens?
A. They are found on all nucleated cells
B. They are found on B cells and Macrophages
C. They all originate at one locus
D. They are coded for on chromosome 9
QUESTION FIFTEEN
All of the following may contribute to autoimmunity except
A. Clonal deletion of self-reactive T-cells
B. Molecular mimicry
C. New expression of class II MHC antigens
D. Polyclonal activation of B cells
QUESTION SIXTEEN
The class of immunoglobulin is determined by
A. The light chain
B. The variable region
C. The J-Chain chain
D. The heavy chain
QUESTION SEVENTEEN
Which of the following immunoglobulin is present in plasma in the highest concentration?
A. IgM
B. Ig A
C. IgCa
D. IgD
QUESTION EIGHTEEN
Antigen-antibody reactions can result in the following
A. Agglutination
B. Complement fixation
C. Virus neutralization
D. Allergic reactions.
QUESTION NINETEEN
One principal function of complement is to
A. Inactivate perforins
B. Mediate release of histamine
C. Bind antibodies attached to cell surfaces and lyse those cells
D. Phagocytize antigens
QUESTION TWENTY
Parasites are able to evade host defenses by which of the following means?
A. Acquisition of host antigens
B. Changing surface antigens
C. Sequestering themselves within host cell
D. All of the above
SECTION B (30MARKS)
QUESTION ONE
Define the following terms
Pathogen
Allergen
Apoptosis
Hematopoiesis
QUESTION TWO
Describe the clinical types of graft rejection
QUESTION THREE
Differentiate between primary and secondary antibody responses
QUESTION FOUR
Compare and contrast innate and adaptive immunity.
QUESTION FIVE
Describe the mechanisms of action of adjuvants.
QUESTION SIX
Describe type 1 hypersensitivity
SECTION C (20MARKS)
QUESTION ONE
a) Discuss the factors that influence immunogenicity. (10marks)
b) Discuss the immunoglobulin classes using diagrams where applicable.
(10marks)
QUESTION TWO
Discuss the etiology of autoimmune diseases. (20marks)
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