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Dpht 032: Pharmacology &Amp; Therapeutics Ii Question Paper

Dpht 032: Pharmacology &Amp; Therapeutics Ii

Course:Pharmacy

Institution: Kenya Methodist University question papers

Exam Year:2012

KENYA METHODIST UNIVERSITY
END OF 2''ND ''TRIMESTER 2012 (DAY) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : PHARMACY
UNIT CODE : DPHT 032
UNIT TITLE : PHARMACOLOGY & THERAPEUTICS II
TIME : 3HOURS

INSTRUCTIONS: Answer ALL Questions
This paper consists of three sections A, B and C
Section A contains Multiple Choice Questions
Section B consists of short answer questions and Section C contain essay Questions
SECTION A (20marks)
QUESTION ONE
The following are bacterial drugs except
A. Chloramphenicol
B. Amoxycillin
C. Cerufoxime
D. Imipenem
QUESTION TWO
Micrographia is a symptom that may be experienced by patient suffering from
A. Epilepsy
B. Parkinsonism
C. Mania
D. Schizophrenia
QUESTION THREE
The following factors may set off seizures except
A. Sleep deprivation
B. Emotional and physical exhaustion
C. Overeating at a party
D. Infectious disease associated with pyrexia
QUESTION FOUR
The following drugs are Beta-lactam anitibiotics except
A. Penicillin
B. Tetracycline
C. Amoxycillin
D. Monobactam
QUESTION FIVE
The drug inhibits folate synthesis by competing with para-amino benzoic acid for dihydropteroate synthetase is
A. Sulphadiazine
B. Amphotericin
C. Rifampicin
D. Gentamicin
QUESTION SIX
Clarithromycin is
A. Aminoglycoside
B. A macrolide
C. A penicillilinase resistant penicillin
D. Polyene antibiotic
QUESTION SEVEN
Which one of the following is the drug of choice in the treatment of petitmal seizures?
A. Phenobarbitone
B. Phenytoin
C. Diazepam
D. Ethosuximide
QUESTION EIGHT
Drug that is preferred in epileptic pregnant women is
A. Valproate
B. Carbomazepine
C. Primidone
D. Phenytoin
QUESTION NINE
In parkinsonism there is
A. Deficiency in dopaminergic activity
B. Deficiency in cholinergic activity
C. Excessive dopaminergic activity
D. Excessive adrenergic activity
QUESTION TEN
A beta-lactam drug that is resistant to - lactamases is
A. Benzylpenicillin
B. Ampicillin
C. Flucloxacillin
D. Amoxycillin
QUESTION ELEVEN
A drug commonly used for management of pneumocystis carnii pneumonia is
A. Cotrimoxazole
B. Isoniazid
C. Rifampicin
D. Sulphodiaxine
QUESTION TWELVE
Which of the following is not a major reason for combination of antibacterial agents?
A. Achieve synergism
B. Reduce cost of therapy
C. Broaden spectrum of activity
D. Reduce severity of side effects
QUESTION THIRTEEN
Which drug is given to prevent transmission of HIV from mother to child?
A. Lamuvidine
B. Effiverenz
C. Neverapine
D. Acyclavor
QUESTION FOURTEEN
A drug that inhibits human DNA gyrase is
A. Doxorubicin
B. Ciprofloxacin
C. Orfloxacin
D. Norfloxacin
QUESTION FIFTEEN
An akylating agent is
A. Vincristine
B. Tamoxifen
C. Cyclophosphamide
D. Metoclopramide
QUESTION SIXTEEN
Methotrexate is
A. Vinca alkaloid
B. Anti-metabolite
C. Cytoloxic antibiotic
D. Hormone
QUESTION SEVENTEEN
A patient receiving monoamine oxidase inhibitor (antidepressants) is advised to avoid:
A. Cheese
B. Milk
C. Oranges
D. Cauliflower
QUESTION EIGHTEEN
There is need to use a purgative after de-worming infestation with
A. Ancylostoma duodenalis
B. Ascaris lubricoides
C. Taenia saginata
D. Taenia solium
QUESTION NINETEEN
An anti-retroviral drug that inhibits the conversion of inactive viral protein into structural and regulating proteins is
A. Abacavir
B. Lamivudine
C. Saquanavir
D. Didanosine
QUESTION TWENTY
The most suitable drug in the management of acne vulgaris is
A. Retinoic acid
B. Benzoyl peroxide
C. Clindamycin
D. Tetracyclines
SECTION B SHORT ANSWER QUESTIONS (25marks)
QUESTION TWENTY ONE
a) Give a reason why chemotherapy is commonly given following surgical
removal of a primary malignant tumour. (3marks)

b) List any FOUR general side effects commonly associated with antineoplastic agents. (2marks)
QUESTION TWENTY TWO
a) Explain why combination therapy is recommended in the management of malaria. (3marks)

b) Give ONE example of artemesinin combination therapy drug available in the market today. (1mark)
QUESTION TWENTY THREE
a) What do you understand by the term super infections? (2marks)

b) State TWO causes of super infections. (2marks)
QUESTION TWENTY FOUR
Give FOUR reasons that would necessitate alteration of anti-retroviral drug regimen. (4marks)
QUESTION TWENTY FIVE
Explain the pharmacological basis for the following drug combinations.
a) Neomycin and Bacitracin in treatment of skin infections. (4marks)

b) Levodopa and carbidopa in parkinsonism. (4marks)
SECTION C ESSAY QUESTIONS (25MARKS)
QUESTION TWENTY SIX
Describe the mode of action for EACH of the following chemotherapeutic drugs:
Primaquine
(4marks)
Albendazole
(4marks)
Nystatin
(4marks)
QUESTION TWENTY SEVEN
Discuss the adverse effects that are associated with long term therapy with antibiotics. (13marks)

Dpht 032: Pharmacology &Amp; Therapeutics Ii Question Paper

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