Dmls 032:Clinical Chemistry Iii Question Paper
Dmls 032:Clinical Chemistry Iii
Course:Medical Laboratory
Institution: Kenya Methodist University question papers
Exam Year:2013
CLINICAL CHEMISTRY III (DLMS 032) 3RD TRIMESTER 2013
KENYA METHODIST UNIVERSITY
END OF 3RDTRIMESTER 2013 (DAY) EXAMINATION
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : MEDICAL LABORATORY
UNIT CODE : DMLS 032
UNIT TITLE : CLINICAL CHEMISTRY III
TIME : 2 HOURS
INSTRUCTIONS : Answer ALL Questions in Section A and B, choose the most appropriate answer in Section A
SECTION A
Question One
In the glucose oxidase method of estimation of blood glucose, glucose is oxidised to:
* Gluconic acid
* Glucaric acid
* glucuronic acid
* All the above.
Question Two
Glucokinase is mainly found in
* Muscle
* Brain
* Liver
* Lungs
Question Three
The main sample taken from a patient during a glucose tolerance test are:
* Blood and saliva
* Blood and urine
* Urine and cerebrospinal fluid
* Blood and cerebrospinal fluid.
Question Four
The main principle in the estimation of blood glucose by the modified Asatoor and king method is:
* Reduction of cupric ions by glucose
* Oxidation of cupric ions by glucose
* Reduction of glucose by glucose oxidase
* Oxidation of glucose by glucose oxidase.
Question Five
Cholesterol and glyceride testing is done for the following except:
* Screen for lipid disorder
* Check for response to medication to treat lipid disorders.
* In such symptom presentation as Xanthomatosis
* Check for the progress of retinoblastoma.
Question Six
Which of the following pair of markers can be used as prostate cancer markers?
* PSA and acid phosphatase
* PSA and alkaline phosphatase
* LDH and PSA
* LDH and acid phosphatase
Question Seven
The approximate volume of CSF in an adult is:
* 300 ml
* 400 ml
* 150 ml
* 250 ml
Question Eight
CSF is formed by the choroid plexus situated within
* Cerebral cortex
* Ventricles
* Celebrrum
* Pons
Question Nine
The normal glucose levels in the CSF is
* 50 – 70 mg/dl
* 20 -40 mg/dl
* 80 – 130mg/dl
* 0 - 20 mg/dl
Question Ten
The Meuleman`s reagent used in the estimation of total protein in CSF is composed of
* Sodium sulphate and sulphosalicylic acid
* Calcium sulphate and sodium sulphate
* Potassium sulphate and sulphosalicylic acid
* Calcium sulphate and sulphosalicylic acid.
Question Eleven
The enzyme that is deficient in phenylketonuria is
* Tyrosinase
* Phenlalanine hydroxylase
* Alanine transferase
* Tyrosine decarboxylase.
Question Twelve
A patient had pigment lacking in his eyes. What condition is this?
* Albinism
* Alkaptonuria
* Phenylketonuria
* Dystrophy.
Question Thirteen
When analyzing a sample, the technician used the wrong wave length. What type of error did he commit.
* Pre analytical error
* Post analytical error
* Analytical error
* None of the above.
Question Fourteen
File:CLINICAL CHEMISTRY III (DLMS 032) 3RD TRIMESTER 2013 01.png
Glutamate
oxaloacetate
This reaction is know as:
* Transamination
* Dehydrogenation
* Deamination
* Carboxylation
Question Fifteen
Conversion of arginine to urea is facilitated by which enzyme?
* Urease
* Argininosuccinate lyase
* Arginase
* Ornithine transcarbamoylase
Question Sixteen
Formation of urea takes place in
* Kidney
* Heart
* Stomach
* Liver
Question Seventeen
An enzyme which converts glucose – 1 – phosphate to glucose – 4 phosphate is referred to as
* Hydrolase
* Isomerase
* Dehydrogenase
* Synthase
Question Eighteen
Which of the following enzyme tests cannot be used to assess liver damage?
* ? glutaryl transferase
* Creatine kinase
* Alkaline phosphatase
* Lactate dehydrogenase.
Question Nineteen
Amino acids that can be synthesized by the body are referred to as:
* Essential amino acids
* Ketogenic amino acids
* Glucogenic amino acids
* Non-essential amino acids.
Question Twenty
Which of the following specimens is not likely to be analysed in a clinical chemistry laboratory?
* Spetum
* Stool
* CSF
* Urine
SECTION B
Question One
Outline the procedure of conducting a glucose tolerance test. (5marks)
Question Two
Outline the markers of bone diseases. (5marks)
Question Three
Briefly describe the principle of the estimation of blood glucose using the glucose oxidase method. (5marks)
Question Four
Outline the markers of prostate cancer. (5marks)
Question Five
* Name FOUR enzymes used in diagnosis.
(2marks)
* In which organs are they applied in diagnosis?
(2marks)
* Define iso enzymes
(1mark)
Question Six
State the sources of pre-analytical errors. (5marks)
Question Seven
A blood sample was hemolysed
* What factors could have caused this hemolysis?
(4marks)
* Name TWO analytes that cannot be assayed from this sample. (1mark)
Question Eight
Write short notes on alkaptonuria. (5marks)
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