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Bioc 403: Clinical Biochemistry Question Paper

Bioc 403: Clinical Biochemistry

Course:Bachelor Of Science

Institution: Egerton University question papers

Exam Year:2012

SECTION A: ANSWER ANY TWO QUESTIONS

1. Discuss lactate dehydrogenase under the following sub-heading: (15 Marks)
a. Tissue distribution
b. Catalytic function
c. Isoenzymes
d. Clinical applications
2. Homeostasis is a perfect balance. Discuss. (15 Marks)
3. Creatinine clearance is a reasonably accurate measure of Glomerular Filtration Rate (GFR) in those situations in
which it is most required.
a. Explain metabolism of creatine and creatinine.
b. Discuss giving analytical approach in its relation to renal function.
c. Explain why measurement of plasma creatinine is recommended in preference to the measurement of urea for the
determination of glomerular function. (15 Marks)

SECTION B: ANSWER ALL QUESTIONS

4. Using specific examples discuss the mechanism of action of the various anticoagulants used to collect blood samples
for laboratory analysis. (10 Marks)
5.(a) Jaundice arises from disorder in bile pigments metabolism. Discuss the various forms and causative factors. (10 Marks)
(b) Describe how each type can be differentiated. (12 Marks)
6. Discuss the relevance and techniques of blood compatibility testing. (10 Marks)
7. Define and explain the clinical importance of the following terms: (8 Marks)
a. Normal reference range
b. Azotemia

Bioc 403: Clinical Biochemistry Question Paper

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