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Bioc 404: Metabolic Regulation And Integrated Metabolism Question Paper

Bioc 404: Metabolic Regulation And Integrated Metabolism

Course:Bachelor Of Science

Institution: Egerton University question papers

Exam Year:2012

SECTION A: ATTEMPT ALL QUESTIONS

1.(a) What is physiological importance of having pyruvate kinase isoenzymes in mammals? (4 Marks)
(b) Briefly describe the different levels of regulation of pyruvate kinase. (6 Marks)
2. Discuss the composition and the regulation of the pyruvate dehydrogenase complex. (10 Marks)
3.(a) Given that the phosphofructokinase-1 (PFK-1) is regulated by insulin but not by (de)phosphorylation, how is this
regulation accomplished? (5 Marks)
(b) Why are metabolic processes regulated? Outline the different levels of regulation. (5 Marks)
4.(a) Acetyl CoA carboxylase is regulated by local metabolites. Elaborate. (5 Marks)
(b) How is the lactose operon regulated when E. Coli grows in medium containing both glucose and lactose. (5 Marks)
5. Discuss the major metabolic functions. (10 Marks)

SECTION B: ATTEMPT ANY TWO QUESTIONS

6. Briefly describe how Beta oxidation is regulated by hormones. (10 Marks)
7. Using a well labelled flow diagram, describe the amplifying cascade mechanism by which hormones activate glycogen
degradation. (10 Marks)
8. Discuss the structural organization and the regulation of the tryptophan operon. (10 Marks)

Bioc 404: Metabolic Regulation And Integrated Metabolism Question Paper

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