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Pps 217; General Pharmacology Question Paper

Pps 217; General Pharmacology

Course:Bachelor Of Science In Pharmaceutical Sciences

Institution: Maseno University question papers

Exam Year:2016

MASENO UNIVERSITY

UNIVERSITY EXAMINATIONS 2016/2017

SECOND YEAR FIRST SEMESTER EXAMINATIONS FOR THE
DEGREE OF BACHELOR OF SCIENCE IN PHARMACEUTICAL SCIENCE
WITH INFORMATION TECHNOLOGY

MAIN CAMPUS

PPS 217:GENERAL PHARMACOLOGY

Date: 3rd December, 2016 Time: 12.00 - 3.00pm

INSTRUCTIONS:
.Answer question ONE and any other FOUR questions.

MASENO UNIVERSITY ISO 9001:2008 CERTIFIED

Q 1.Using specific examples, briefly explain the following terms as they are used in pharmacology and OR therapeutics (25 Marks)

a)Differences in Enteral and Parenteral routes of Drug administration (5 Marks)

b)Drug affinity and intrinsic activity (5 Marks)

c)First pass effect (5 Marks)

d)Drug elimination (5 Marks)

e)Relevance of Therapeutic Index (TI) in relation to margin of safety of a drug (5 Marks)

Q 2.Discuss the various methods used in the measurements or analysis of drug levels in the body and why its is important to maintain effective plasma drug concentration (15 Marks)

Q 3.What do you understand by the terminology "Malignancy" and what is the mechanism in the selectivity of action of various drugs used in the chemotherapeutic management of malignant diseases (15 Marks)

Q 4.Discuss the metabolic pathway of highly active antiretroviral drugs (HAART), effects and therapeutic use of HAART (15 Marks)

Q 5.Using examples where necessary, discuss the pharmacological actions and the common unwanted effects of Non-Steroidal Anti-Inflammatory drugs (NDAIDs) (15 Marks)

Q 6.Discuss the mechanisms of antibiotic resistance in the current regimens in the treatment of bacterial infections and how resistance can be overcome (15 Marks)

Pps 217; General Pharmacology Question Paper

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