Pmb 323: Medical Virology Question Paper
Pmb 323: Medical Virology
Course:Bachelor Of Science In Medical Biotechnology
Institution: Maseno University question papers
Exam Year:2016
MASENO UNIVERSITY
UNIVERSITY EXAMINATIONS 2015/2016
THIRD YEAR SECOND SEMESTER EXAMINATIONS FOR THE DEGREE
OF BACHELOR OF SCIENCE IN MEDICAL BIOTECHNOLOGY WITH
INFORMATION TECHNOLOGY
MAIN CAMPUS
PMB 323: MEDICAL VIROLOGY
Date: 18th April, 2016 Time: 11.00-1.00pm
INSTRUCTIONS:
.Answer ALL questions in SECTION A and any TWO in SECTION B.
MASENO UNIVERSITY ISO 9001:2008 CERTIFIED
SECTION A: Answer ALL Questions
Q 1.What do you understand by the term "Viruses" and how do they differ from "Plasmids"? (4 marks)
Q 2.How do positive-stranded RNA viruses differ from negative-stranded RNA viruses in terms of their cellular infectivity (5 marks)
Q 3.How does the paralytic stage of Poliomyelitis arise?(6 marks)
Q 4.For each of the following viruses indicate;
a)Whether it is enveloped or non-enveloped(10 marks)
b)The nature of its nucleic acid(single-stranded, double-stranded, type of nucleic acid and nucleotides) (10 marks)
c)Strategy in the synthesis of its genome(15 marks)
d)Presenting clinical symptoms(10 marks)
e)How it is managed(5 marks)
VIRUSES;
i)Human Influenza virus
ii)Hepatitis B virus
iii)Herpes Simplex Virus type I
iv)Human Immunodeficiency virus
v)Human Papilloma virus
SECTION B: Answer Question 5 and either Question 6 OR Question 7
Q 5.Discuss the mechanisms by which the following drugs when combined achieve optimum anti-virus chemotherapeutic activities and thereby minimize development of resistance(20 marks)
a)Azidothymidine and Dideoxycytidine
b)A Protease Inhibitor
Q 6.Discuss the biochemical basis for the success of anti-herpes drugs like Acyclovir and 5-Methoxymethyl deoxycytidine in treatment of Herpes labialis or Herpes genitalis in human(15 marks)
Q 7.List cancers usually seen in people infected with Human Immunodeficiency Virus-I and briefly explain the mechanism by which they arise.(15 marks)
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