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Pmt 443: Pharmaceutical Chemistry And Biopharmaceutics Question Paper

Pmt 443: Pharmaceutical Chemistry And Biopharmaceutics

Course:Bachelor Of Science In Medical Biotechnology

Institution: Maseno University question papers

Exam Year:2011

MASENO UNIVERSITY

UNIVERSITY EXAMINATIONS 2010/2011

FOURTH YEAR SECOND SEMESTER EXAMINATION

FOR THE DEGREE OF BACHELOR OF SCIENCE IN

BIOMEDICAL SCIENCE TECHNOLOGY WITH IT

(MAIN CAMPUS)

PMT 443: PHARMACEUTICAL CHEMISTRY AND BIO-PHARMACEUTICS

Date: 19" April, 2011 Time: 2.00-4;00 p.m.

INSTRUCTIONS:

.This paper consists Of two sections, A B.

.Answer ALL questions in SECTION A and TWO questions in

SECTION B.

SECTION A (30 marks). Attempt ALL the questions.

1. A medicinal chemist synthesized a compound which, on evaluation was found to have properties of a drug-like molecule. Briefly discuss these properties (10 marks)

2. PURECAL is a calcium supplement given to patients in calcium - deficiency states. Discuss how to determine calcium content of tablets of this product by complex metric titration (10 marks)

3. Discuss how the state of ionization of a drug may affect its pharmacological action (10 marks).

SECTION B:

Attempt any TWO questions from this section (40 marks).

5. a) Benzodiazepines are commonly used as sedatives, anxyolytics and anti-convulsants. Discuss how the structure-activity relationships influence pharmacological action of this class Of drugs (14 marks)

b) Barbiturates are acidic. Using their chemical structure discuss the basis of their acidity (6 marks)

6. (a) Discuss the use Of polarimetry in analysis of selected compound of pharmaceutical significance (12 marks)

(b) Using specific examples, discuss how stereo chemistry affects pharmacological action of drugs
(8 marks)

7. (a) Explain the Beer-Lambert's Law (5 marks).

(b) How is it applied in Pharmaceutical analysis? (5 marks)

(c) Discuss how infrared spectroscopy can be used in elucidation of chemical structure of a drug molecule (10 marks)

Pmt 443: Pharmaceutical Chemistry And Biopharmaceutics Question Paper

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