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Pmb 448: Principles Of Genomics And Proteomics Question Paper

Pmb 448: Principles Of Genomics And Proteomics

Course:Bachelor Of Science In Medical Biotechnology

Institution: Maseno University question papers

Exam Year:2013

MASENO UNIVERSITY

UNIVERSITY EXAMINATIONS 2012/2013

FOURTH YEAR SECOND SEMESTER EXAMINATIONS

FOR THE DEGREE OF BACHELOR SCIENCE IN

MEDICAL BIOTECHNOLOGY WITH INFORMATION

TECHNOLOGY

(MAIN CAMPUS)

PMB 448: PRINCIPLES OF GENOMICS AND PROTEOMICS

Date: 5th April, 2013 Time: 8.30 -10.30am

MASENO UNIVERSITY ISO 9001:2008 CERTIFIED

PMB 448: Principles of Genomics and proteomics

Bachelor of Science in Medical Biotechnology

Section A

Instructions: answer all questions in this section.

I.Is protein chemistry same as proteomics, Explain your answer(5 marks)

2. Define the following terms (5 marks)

i) tblastx

ii) CpG islands

iii) Microsatellites

iv) Expressed sequence tags

V) Mapping reagent

3. Using a figure Where appropriate shortly describe the page electrophoresis and its application in post genomics/proteomics studies (5 Marks)

4. For analysis using Mass Spectrometry, Protein Peptide ions are usually fragmented; briefly delineate the nomenclature used to describe this peptide ion fragmentation.(5 marks)

5. Shortly describe how real genes may be distinguished from chance ORFs within a genome (5 marks)

6. What is peptide mass finger-printing (5 marks)

7. Describe Clone Contig assembly by chromosome walking (5 marks)

8. Shortly describe what the term Genome Wide Associated Studies entails
(5 marks)

PART B

Instructions: Question 9 is compulsory; additionally answer One question between Questions 10 and 11.

9. The Fourth year class in the school of genome sciences at Maseno University has been tasked with re-sequencing the bacterium Hoemophilus influenzae genome, using the shotgun approach to genome sequencing. give a detailed account of how they would go about this task. (15 MARKS)

10. MercOnyango Japunda would like to study the transcriptome of yeast cells under environmental stress in comparison to normal yeast cells, what tool will he use and how will he go about his study. (15 marks)

11. Describe how proteomic analysis may be accomplished using the MALDI-TOF Mass spectrometry. (15 marks)

Pmb 448: Principles Of Genomics And Proteomics Question Paper

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