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Pmt 427: Analysis Of Toxic And Therapeutic Substances Question Paper

Pmt 427: Analysis Of Toxic And Therapeutic Substances

Course:Bachelor Of Science In Medical Laboratory Sciences

Institution: Maseno University question papers

Exam Year:2013

MASENO UNIVERSITY

UNIVERSITY EXAMINATIONS 2012/2013

FOURTH YEAR SECOND SEMESTER EXAMINATION

FOR THE DEGREE OF BACHELOR OF SCIENCE IN

MEDICAL BIOTECHNOLOGY; BACHELOR OF SCIENCE

IN PHARMACEUTICAL SCIENCE; BACHELOR OF

SCIENCE IN MEDICAL LABORATORY SCIENCE WITH

INFORMATION TECHNOLOGY

(MAIN CAMPUS)

PMT 427: ANALYSIS OF TOXIC AND THERAPEUTIC SUBSTANCES

Date: 4th April, 2013 Time: 11.00 a.m. — p.m

INSTRUCTIONS:

. Carefully read the instructions on the answer booklet provided.

. Ensure that you write your admission number on every piece of paper you use.

. Section A is made of SAQs and carries 40 marks.

• Section B consists of LAQs and carries 30 marks.

MASENO UNIVERSITY ISO 9001:2008 CERTIFIED

Section A: SAQs : 40 marks; answer all

1.Define the following terms: (5 marks)

a. Toxin

b. Toxicant

c. Steady State concentration ( CSS)

d- Therapeutic range

e. drug monitoring (TDM)

2.Name five classes Of common toxic substances and give example for each Class (5 marks)

3.List five main biological samples used in toxicological and therapeutic drug analysis (5 marks)

4.Explain Why Whole blood W the preferred sample in the quantitative analysis of (3 marks)

5.a) What is a reference reagent (2 marks)

b) Explain the purpose of reference Compounds in drug and toxicological analysis (3 marks)

6.Describe the principles Of the following analytical methods used in therapeutic drug analysis
(6 marks)

a. Particle Enhanced Turbidimetrie Inhibition Immunoassay (PETTNIA)

b. Affinity Chrome—Mediated Immunoassay (ACMIA)

c. Cloned Enzyme Donor Immunoassay (CEDIA)

7.Describe the information need to accurately interpret drug analysis results in therapeutic drug monitoring (5 marks)

8.Describe the general policies that can improve the accuracy and reliability Of analytical laboratory results (6 marks)

Section B consists of LAQS and carries 30 marks. Answer any two (30 marks)

1.Discuss in detail thin layer Chromatography (TLC) technique and its application in drug and toxicant analysis (15 marks)

2.Discuss the various aspects of antiepileptic therapeutic drug monitoring (15 marks)

3.Discuss five factors that affect antimicrobial susceptibility test results (15 marks)

4.Disscuss qualitative color tests for the following substances (15 marks)

a. Salicylic acid

b. henothiazines

c. Imipramine

d. paracetamol

e. Paraquat

Pmt 427: Analysis Of Toxic And Therapeutic Substances Question Paper

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