The germ theory of disease states that microorganisms known as pathogens or "germs" can lead to disease. These small organisms, too small to be seen with naked eyes, invade humans, other animals, and other living hosts. Their growth and reproduction within their hosts can cause disease. "Germ" may refer to not just a bacterium but to any type of microorganism or even non-living pathogen that can cause disease, such as protists, fungi, viruses, prions, or viroids.A microbe suspected as the causal agent of a particular disease must be found in all subjects suffering from a similar disease but must be absent in clinical specimens from healthy individuals.
The suspected microorganism can be isolated from the diseased individual and grown in pure culture.
When this isolated suspect microbe is injected into healthy, susceptible animals, signs and symptoms of a disease similar to the disease under investigation must develop in the infected animal.
The microbe cultured from the infected animal must be morphologically and physiologically identical to the strain initially isolated from the patient.
Both point at proving that microbres are disease causing agents
otienosam answered the question on April 6, 2020 at 13:23
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